The impact of predictive genetic testing for hereditary nonpolyposis colorectal cancer: three years after testing
نویسندگان
چکیده
منابع مشابه
Interpretation of genetic test results for hereditary nonpolyposis colorectal cancer: implications for clinical predisposition testing.
CONTEXT Genetic testing for cancer predisposition is evolving from purely research applications to affecting clinical management. OBJECTIVE To determine how often genetic test results for hereditary nonpolyposis colorectal cancer (HNPCC) can be definitively interpreted and used to guide clinical management. DESIGN Case-series study conducted in 1996 to 1998 in which a complete sequence anal...
متن کاملGenetic testing in families with hereditary nonpolyposis colon cancer.
CONTEXT Genetic testing for hereditary nonpolyposis colon cancer (HNPCC) is available, but the rates of acceptance of testing or barriers to participation are not known. OBJECTIVE To investigate rates and predictors of utilization of genetic testing for HNPCC. DESIGN Cohort study conducted between July 1996 and July 1998. SETTING Hereditary nonpolyposis colon cancer family registry. PAR...
متن کاملGenetic counseling in hereditary nonpolyposis colorectal cancer.
Recent identification of gene mutations responsible for hereditary nonpolyposis colorectal cancer (HNPCC) has made possible the presymptomatic diagnosis of at-risk family members. If DNA testing shows that a family member is a gene carrier, that individual's lifetime cancer risk is approximately 90%. If the test is negative, the family member's cancer risk drops to that of the general populatio...
متن کاملA social network analysis of communication about hereditary nonpolyposis colorectal cancer genetic testing and family functioning.
Hereditary cancers are relational diseases. A primary focus of research in the past has been the biological relations that exist within the families and how genes are passed along family lines. However, hereditary cancers are relational in a psychosocial sense, as well. They can impact communication relationships within a family, as well as support relationships among family members. Furthermor...
متن کاملHereditary nonpolyposis colorectal cancer.
Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, is the most common form of hereditary colorectal cancer (CRC). A well-orchestrated cancer family history is essential for its diagnosis since, unlike its familial adenomatous polyposis (FAP) hereditary cancer counterpart, HNPCC lacks distinguishing clinical stigmata of its cancer genetic risk. Discoveries in the 1990s of germ...
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ژورنال
عنوان ژورنال: Genetics in Medicine
سال: 2007
ISSN: 1098-3600,1530-0366
DOI: 10.1097/gim.0b013e31804b45db